Liver Anatomy, Function, and Ultrasound Principles Practice Test 2026 – Comprehensive All-in-One Guide for Medical Students

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AFP is produced by which cells in adults?

Neurons

Adipocytes

Skeletal Muscle Cells

Hepatocytes

AFP is a fetal glycoprotein produced mainly by the liver (hepatocytes) and yolk sac. After birth, normal production drops and adult liver cells do not actively secrete AFP. If AFP is elevated in adults, it most often comes from hepatocytes that re-express AFP in disease, such as hepatocellular carcinoma, or from certain germ cell tumors. So the cells responsible in adults are hepatocytes. Neurons, adipocytes, and skeletal muscle cells do not produce AFP.